SPARTANBURG, S.C. – Featuring six opponents returning to the slate from a season ago, three Power-Four programs, and two games against 2025 NCAA Tournament qualifiers, USC Upstate women's basketball and head coach Jason Williams announce the Spartans' 14-game 2025-26 non-conference schedule.
 
The season begins for the Spartans in the Upstate, facing Clemson for the third time in the program's Division I era (2007-pres.) on Nov. 3, the first of three Power-Four opponents for Upstate during the month of November. The meeting marks the second straight season Upstate opens on the road against a Power-Four program and the first time opening a season against the Tigers since 2021-22.
 
In the second contest of the campaign, Upstate returns to the G.B. Hodge Center for the first time, hosting Erskine on Nov. 6. Following the team's home opener, the Spartans return to the road for a pair of matchups with Southeastern Conference opposition, heading to Georgia and Kentucky on Nov. 10 and Nov. 12, respectively. The set sees Upstate return to Athens for the first time since the 2019-20 campaign and return to Lexington for the second straight season.
 
On Nov. 17, the Spartans return to the friendly confines of the Hodge against South Carolina State before returning to the road for an MTE at Morehead State. The two-game event sees Upstate take on Marshall and the host Eagles on Nov. 21 and Nov. 22, respectively.
 
The Spartans close the season's opening month hosting Montreat on Nov. 25 before hitting the road for Kennesaw State on Nov. 28. December begins with Upstate taking a trip to Western Carolina on Dec. 3, the team's penultimate road contest of non-conference play.
 
Upstate's longest homestand of its non-league slate begins against UNCG on Dec. 6 before continuing against Samford on Dec. 14 and culminating versus Agnes Scott on Dec. 17. The team's final non-conference clash takes place Dec. 20 with Upstate heading to Queens.
 
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